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Individuals with certain genetic conditions, like Lebers disease, where high B12 can worsen vision problems

Epidemiological evidence in some cases hints that the accepted dosages of vitamin B helps only to avoid their marginal deficiency and further benefits could accrue from higher dosages than those provided by RDA (4-5)

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Many athletes incorporate post-training cold water immersion as a permanent practice rather than a time-limited intervention

When these reactions are mild, they typically aren't cause for concern